ELISA – Conception and Applications

19th August 2015

Category: Bioanalytical / Biosimilars

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By: Laura Munro, Technical Services Scientist,

Since its conception in the early 1970’s the Enzyme Linked Immunosorbent Assay (ELISA) has been a primary method of analyte detection. In its four decades it has become a fundamental tool in a wide range of scientific fields, its diverse nature demonstrated by its range of uses. The ELISA was the first screening test widely used More

An Orthogonal Approach to ADCC Biosimilar Testing

Category: Biosimilars

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By: Debbie Allan PhD, Technical Services Scientist,

Antibody-Dependent Cellular Cytotoxicity (ADCC) is a mechanism adopted by the immune system to remove infected or cancerous cells. Antibodies bind a specific antigen on the target cell surface which in turn binds the FcγRIIIa receptor on effector cells (e.g. Natural Killer (NK) cells) via the Fc region, resulting in the lysis of the target cell. More

The Importance of Accurate Determination of ADCC Activity During Biosimilar Development

Category: Biosimilars

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By: Stefan Termen, Technical Services Scientist,

Cells infected with enveloped viruses will express viral proteins on their cell membranes, and many cancer cells will express specific surface antigens. These proteins are recognized by antibodies of the humoral immune system as targets for Antibody-Dependent Cell-mediated Cytotoxicity (ADCC). In this process, effector cells of the immune system recognize the bound antibodies through their More

Cost and Time Effective Approach to Early Stage Biosimilar Development: A Case Study of Tocilizumab

Category: Biosimilars

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By: Dr Terry Gray, Field Marketing Manager,

Introduction to Tocilizumab (Actemra) Tocilizumab (Actemra (US)/RoActemra (EU)) is a therapeutic monoclonal antibody that targets the Interleukin-6 receptor (IL-6R).  Interleukin-6 (IL-6) is a multifunctional cytokine which is central to the regulation of the immune and nervous systems.  This molecule has been linked to pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) due to aberrations More

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