Qualifying & Developing VEGF Binding Assay using an iQue® Screener PLUS

25th May 2018

Category: Bioanalytical

By: Ben Tyrrell, PhD - Scientist, Product Development, Katie Chapple - Scientist,

The iQue® Screener PLUS, by Intellicyt (part of the Sartorius Group), is used at Sartorius Stedim BioOutsource to achieve a faster assay throughput and deliver an air-gap-deliminated flow of samples to the detectors. Bevacizumab is a humanized monoclonal antibody (mAb) which mediates its activity through a high affinity binding to VEGF (vascular endothelial growth factor). More

Robust & Reproducible ADCC with Single Donor KILR CD16 Effector Cells

23rd May 2018

Category: Bioanalytical

By: Laura McAleer, Technical Services Scientist, Lisa Blackwood, PhD - Senior Scientist, Product Development,

The success of ADCC (antibody-dependent cell-mediated cytotoxicity) depends on the quality of the effector cells used. Traditional ADCC assays can be complex and require freshly isolated primary human cells, such as PBMC (peripheral blood mononuclear cell) or NK (natural killer) cells. However these can have inter-individual variability. While NK cell lines engineered to overexpress CD16 are More

The Path to Protein Concentration Measurement

8th May 2018

Category: Bioanalytical

Tags: , ,

By: Stuart Wright - Scientist,

Protein Concentration Analysis Quick and accurate measurement of protein concentration is very important within the biopharmaceutical industry. This must be carried out on a large number of samples prior to performing the various physicochemical analysis involved in protein characterization or protein structural analysis, since many assays depend on knowledge of the biotherapeutic protein concentration. However, More

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