Comparative Assessment of mAb C1q Binding Using a Sensitive SPR Assay

21st January 2019

Category: Bioanalytical

By: Daniel O'Loughlin - Scientist, Technical Services,

Developing a Method for a Complex Molecular Interaction Effector functions such as complement dependent cytotoxicity (CDC) are important modes of action for many therapeutic monoclonal antibodies (mAbs). The degree of C1q binding and resultant CDC activity can influence the safety and efficacy of a mAb and therefore requires characterization during the development process. In addition, More

What is Mycoplasma?

11th January 2019

Category: Biosafety

By: Daniel Cozens - Biosafety Scientist,

Mycoplasmas are the smallest self-replicating organisms currently known to science. Common in nature, they are a group of simple bacteria characterized by a lack of a cell wall and a small genome. Many Mycoplasma species are found in the respiratory tracts of animals, where they have been associated with disease. For example, Mycoplasma pneumoniae is More

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