Improved Characterization of IgG2 isoforms by LC-MS

2nd May 2019

Category: Bioanalytical / Biosimilars

By: Dr Martin De Cecco - Senior Scientist,

The majority of therapeutic mAbs developed so far belong to the IgG1 subclass, although some are IgG2 or IgG4. These different IgG subclasses differ in terms of the connectivity of their disulfide bonds. Whereas IgG1 molecules generally only have one defined structure, IgG2 antibodies can exist as three isoforms1, each with a different pattern of More

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