Avastin C1q Binding Assays
BioOutsource offers off-the-shelf Avastin C1q binding assays to support Avastin biosimilar manufacture, process development, characterization and similarity studies. We offer industry leading Avastin comparability and Avastin characterization services and these can be adapted for your product where necessary.
The complement system complements the ability of antibodies to clear pathogens and cancerous cells from the body. It is a collection of small proteins present in the blood that typically circulate as inactive precursors. The classical pathway is triggered by activation of the C1-complex which is composed of a single C1q molecule with 2 molecules of C1r and C1s, and occurs when C1q binds multiple IgG molecules complexed with antigen; this can lead to a signalling cascade culminating in complement-dependent cytotoxicity (CDC). Activation of complement is experimentally determined using the C1q binding assay.