Tag: intact mass analysis

Characterization of Protein Structure: The Value of Intact Mass Analysis

26th February 2018

Category: Bioanalytical

Tags: intact mass analysis, peptide mapping, protein characterization

By: Dr Martin De Cecco - Senior Scientist,

Intact mass analysis is the assessment of a protein’s total molecular weight  by mass spectrometry (MS) without prior digestion or fragmentation of the molecule of interest. Molecular weight determination forms part of the ICH Q6B guidelines for physicochemical analysis of biological products: what use is this information in the analytical characterization of biopharmaceuticals? High resolution More