Tag: intact mass analysis
Characterization of Protein Structure: The Value of Intact Mass Analysis
26th February 2018
Category: Bioanalytical
Tags: intact mass analysis, peptide mapping, protein characterization
By: Dr Martin De Cecco - Senior Scientist,
Intact mass analysis is the assessment of a protein’s total molecular weight by mass spectrometry (MS) without prior digestion or fragmentation of the molecule of interest. Molecular weight determination forms part of the ICH Q6B guidelines for physicochemical analysis of biological products: what use is this information in the analytical characterization of biopharmaceuticals? High resolution More