Tag: Orthogonal methods

Orthogonal Chromatographic Techniques for Therapeutic Protein Characterization

1st March 2018

Category: Bioanalytical

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By: Stuart Wright - Scientist,

Development of biotherapeutics, for example monoclonal antibodies (mAbs), requires a wide range of physicochemical and structural analysis to be undertaken in accordance with ICH Q6B guidelines. Each technique will assess different critical quality attributes (CQAs) which form part of the analytical characterization of the biotherapeutic. CQAs are properties or characteristics relating to physical, chemical, biological More

An Orthogonal Approach to ADCC Biosimilar Testing

19th August 2015

Category: Biosimilars

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By: Debbie Allan PhD, Technical Services Scientist,

Antibody-Dependent Cellular Cytotoxicity (ADCC) is a mechanism adopted by the immune system to remove infected or cancerous cells. Antibodies bind a specific antigen on the target cell surface which in turn binds the FcγRIIIa receptor on effector cells (e.g. Natural Killer (NK) cells) via the Fc region, resulting in the lysis of the target cell. More

Cost and Time Effective Approach to Early Stage Biosimilar Development: A Case Study of Tocilizumab

Category: Biosimilars

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By: Dr Terry Gray, Field Marketing Manager,

Introduction to Tocilizumab (Actemra) Tocilizumab (Actemra (US)/RoActemra (EU)) is a therapeutic monoclonal antibody that targets the Interleukin-6 receptor (IL-6R).  Interleukin-6 (IL-6) is a multifunctional cytokine which is central to the regulation of the immune and nervous systems.  This molecule has been linked to pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) due to aberrations More

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