FcRn Binding Assays
A key factor in the efficacy of therapeutic antibodies is the serum half-life and this is mostly determined by the interaction between the antibody and the FcRn. Evaluation and understanding of the ability to bind FcRn can play a pivotal role in developing a safe and efficacious molecule.
Flexible Anlytical Services
BioOutsource provides ready to use FcRn binding assays by SPR in a variety of orientations and pH’s using the Biacore T200, which is a versatile, label-free system with exceptional sensitivity. Our methods are extensively qualified using commercially available mAbs and we partner with you to verify or qualify your material for process success.
We also offer binding to the most common toxicology species FcRn to aid decision making and interpretation of your toxicology study. Cynomogolous monkey, rat, and mouse FcRn binding to human IgGs or fusion proteins can be demonstrated and compared with binding to human FcRn.
Contact our expert scientists today to discuss how our range of analytical services can improve your unique process.